基本信息:
姓名:李健
性别:男
出生日期:1970年9月
职务、职称、社会兼职:AV影片 组胚教研室主任、教授、学位委员会委员
学习经历:
2010年4月-2012年4月 中国中医科AV影片 中医临床基础医学研究所 博士后
2002年9月-2005年7月 AV影片 中西医结合基础专业博士研究生
1996年9月-1999年7月 河北师范大学生命科学AV影片 人体及动物生理专业 硕士研究生
工作经历:
2005年8月至今 AV影片 组胚教研室,教授
1999年8月-2002年8月 河北师范大学生命科学AV影片 人体解剖组织学教研室 讲师
招生专业及研究方向:
招生层次:硕、博士
招生专业:中西医结合基础
研究方向:中医药防治慢性非可控炎症相关疾病(脂肪肝、非酒精性脂肪性肝炎、肝纤维化、动脉粥样硬化等)的作用机制
承担课题(2019年至今):
1)国家自然科学基金面上项目:从“有故无殒”理论探究自噬在雷公藤肝脏毒性中的作用及机制(No. 81873099),2019.1-2022.12,已结题
2)国家自然科学基金面上项目:从肝络学说探究益气通络法调控LECT-2/Tie-1通路干预肝纤维化的作用机制(No.82374181),2024.1-2027.12,在研中
3)校级课题:基于胆酸盐代谢模式探究肝主疏泄的科学内涵(揭榜挂帅重点项目2023-JYB-JBZD-036),2023.06-2025.12,在研中
研究成果(2019年至今):
1.Jiang S, Jiang Y, Feng J, Hou J, Qin Z, Wang Y, Yang K, Li J†. Triptolide combined with salvianolic acid B alleviates CCL4-induced liver fibrosis by suppressing the Th17/IL-17A axis. Int Immunopharmacol. 2025; 26, 150:114300. doi: 10.1016/j.intimp.2025.114300(通讯作者)
2.Shiyuan Jiang, Feng Wan, Hui Lian, Zhihao Lu, Xueming Li, Dan Cao, Yangyu Jiang, Jian Li†. Friend or foe? The dual role of triptolide in the liver, kidney, and heart. Biomedicine & Pharmacotherapy . 2023,161:114470. Doi: 10.1016/j.biopha.2023.114470(通讯作者)
3.Jiang S, Feng J, Jiang Y, Lu Z, Kong J, Li X, Lian H, Zhang F, Li Y, Li J†. Triptolide attenuates CCL4-induced liver fibrosis by regulating the differentiation of CD4+ T cells in mice. Int Immunopharmacol. 2023;125:111206. doi: 10.1016/j.intimp.2023.111206(通讯作者)
4.Dan Cao, Qi-qi Fan, Zhi-qi Li, Mei-lin Chen, Yang-yu Jiang, Rui-chao Lin†, Jian Li†, Chong-jun Zhao†. Transcriptomic profiling revealed the role of apigenin-4-O-α-L-rhamnoside in inhibiting the activation of rheumatoid arthritis fibroblast-like synoviocytes via MAPK signaling pathway. Phytomedicine. 2022. 20;102:154201(共同通讯作者).
5.Hai-yan Wang, Dan Cao, Mei-xian Wang, Yan-bin Shi, Bo-wen Wei, Shi-yuan Jiang, Yang-yu Jiang, Hui Lian, Xiao-ou Xue, Zhi-qiang Ma†, Jian Li†. Proteomic Analysis of Human Follicular Fluid Reveals the Pharmacological Mechanisms of the Chinese Patent Drug Kunling Pill for Improving Diminished Ovarian Reserve. Evidence-based Complementary and Alternative Medicine. 2022;28: 5929694. doi: 10.1155/2022/5929694(共同通讯作者)
6.Dan Cao, Chong-jun Zhao, Zhi-qi Li, Qi-qi Fan, Mei-lin Chen, Yang-yu Jiang, Hai-yan Wang, Han-jun Ning, Rui-chao Lin†, Jian Li†. Combined Metabolomics and Network Toxicology to Explore the Molecular Mechanism of Phytolacca acinose Roxb. Induced Hepatotoxicity in Zebrafish Larvae in Vivo. Evidence-based Complementary and Alternative Medicine. 2021;28: 3303014. doi: 10.1155/2021/3303014.(共同通讯作者)
7.Qing-Hong Du†, Chu-Jun Zhang†, Wei-Hong Li , Yan Mu , Ya Xu , Scott Lowe , Lin Han , Xue Yu , Shu-Yan Wang , Yu Li , Jian Li. Gan Shen Fu Fang ameliorates liver fibrosis in vitro and in vivo by inhibiting the inflammatory response and extracellular signal-regulated kinase phosphorylation. World J Gastroenterol. 2020, 26(21):2810-2820(通讯作者)
8.Tian G†, Wu C†, Li Jian†, Liang B, Zhang F, Fan X, Li Z, Wang Y, Li Z, Liu D, Lai-Han Leung E, Chen J, Network Pharmacology Based investigation into the Effect and mechanism of Modified Sijunzi Decoction against the subtypes of Chronic Atrophic Gastritis, Pharmacological Research. 2019; 144:158-166. //doi.org/10.1016/j.phrs.2019.04.012 (同等贡献第一作者)
9.Li C, Li Z, Zhang T, Wei P, Li N, Zhang W, Ding X, Li J. 1H NMR-Based Metabolomics Reveals the Antitumor Mechanisms of Triptolide in BALB/c Mice Bearing CT26 Tumors. Front Pharmacol. 2019 Oct 11;10:1175. doi: 10.3389/fphar.2019.01175(通讯作者)
招生邮箱:[email protected]